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In vivo reports show anatomically selective neurochemical effects of modafinil on monoaminergic units (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, when modafinil boosts TMN fos expression (Scammell et al 2000) and HAergic tone it's not able to exert this outcome when administered immediately in to the TMN (Ishizuka et al 2003).
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